Scientist, In Vivo Pharmacology

Scientist, In Vivo Pharmacology

Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize the therapeutic index by localizing anti-tumor activity within the tumor microenvironment. Learn more by visiting www.xiliotx.com and follow us on LinkedIn (Xilio Therapeutics, Inc.).

SUMMARY: 

The Scientist, In Vivo Pharmacology is a key contributor in Xilio’s In Vivo Pharmacology group. This person is responsible for developing and running in vivo oncology efficacy models, and pharmacokinetic and pharmacodynamic studies for the characterization of immuno-oncology focused protein therapeutics. The Scientist, In Vivo Pharmacology, collaborates with internal team members to successfully execute studies. This important role will have the opportunity to represent in vivo pharmacology on project teams and reports directly to the Sr. Director, In Vivo Pharmacology.

Job Responsibilities:

• Work with project teams to identify and develop the appropriate in vivo tumor models for testing the efficacy and safety of Xilio’s protein therapeutics.
• Design and execute studies to investigate the efficacy, safety and PK/PD of protein therapeutics including analysis of data with the appropriate statistical tools.
• Initiate, dose and take down in vivo studies; generate PK/PD data.
• Meet all guidelines set forth by Xilio’s IACUC.
• Work with CROs, collaborators and partners to execute studies to support the discovery and optimization of protein therapeutics and to support translational studies to inform upon clinical development plans.
• Identify and integrate technologies that improve or expand the ability to assess molecules in vivo by working with teammates, collaborators, vendors, and staying abreast of the literature.
• Ensure data is captured in appropriate databases and electronic laboratory notebooks.
• Represent in vivo pharmacology in project team meetings and regularly participate in departmental meetings.

Skills, Qualifications, and Requirements:

• Ph.D. (0-1 years’ experience) or M.S. (2+ years’ experience) in Biology, Immuno-Oncology or related field. Prior experience working directly in the life sciences industry (e.g., CRO, biotechnology, or pharmaceutical company) is preferred.
• Hands-on technical experience with development, qualification, and execution of studies in CDX humanized tumor models, as well as syngeneic tumor models is essential.
• Experience with pharmacokinetic analyses would be preferred.
• Experience with FACS analyses of in vivo models is desirable.
• Experience writing reports for regulatory documents would be preferred.
• Goal oriented, organized, capable of working on multiple projects, and able to execute to timelines that meet company goals.
• Work well in a cross-functional team environment, both independently as well as be willing to help others.
• Excellent verbal and written communication skills.
• Ability and willingness to work 100% of time in Xilio’s Waltham, MA office.

Diversity, Equity and Inclusion

At Xilio Therapeutics, we foster a culture of equity, diversity and inclusion.  We consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.  We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability who requires an accommodation with the hiring process or to perform any essential functions of the position for which you are applying, please reach out to [email protected].

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