Principal Software Engineer

Astera Institute

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Emeryville HQ on site Until 8/21/2026 H-1B sponsor history First posted January 29, 2026 Last posted January 29, 2026
Job description

About Astera

Astera is a private foundation with a $2.5B endowment on a mission to steer science and technology toward an abundant future for all. Unlike traditional foundations, we operate like a high-velocity startup with unprecedented access to computational resources and complete freedom from funding pressures or profit motives. This allows us to focus on ambitious goals and attract incredibly creative scientists and engineers from leading academic institutions and from frontier AI labs.

Neuro-AI is our large-scale AI research program, pursuing a neuroscience-informed approach to engineering AGI. This is not yet-another-lab scaling LLMs in a hope of achieving general intelligence. We are integrating neuroscience, AI, and bioengineering to understand and digitally model the architecture of the human brain.

Position Summary

We are looking for an ambitious Staff Software Engineer to help us reverse-engineer the human brain.

This role spans a broad spectrum of activities:

  • Define and architect high-performance infrastructure for training large-scale models and running complex simulations.

  • Design and optimize custom RL environments informed by neuroscience.

  • Set the organizational standard for clean, fast, production-grade code that boosts our research velocity.

  • Turn research prototypes into scalable production systems.

  • Identify and resolve the most critical and ambiguous technical bottlenecks, from low-level optimization to high-level strategy, to unblock the research team.

Qualifications

  • High-Velocity Craftsmanship: You set the bar for clean, maintainable, and well-tested code at a startup pace. You know how to balance engineering rigor with the need to iterate quickly on research prototypes.

  • System Architecture Intuition: You have proven success architecting complex systems from scratch. You understand multi-year trade-offs, and you can design infrastructure that survives the chaos of research.

  • Extreme Adaptability: You might be an expert in distributed systems today, but you are ready to become a novice in neuroscience tomorrow. You have a track record of diving into complex domains, mastering them quickly, and guiding others through them.

  • Mastery of Hard Problems: You have a track record of leading the resolution of difficult engineering challenges, whether it is massive scale distributed systems or kernel-level optimization. You do not shy away from what your peers consider hardcore.

Location & Visa

  • This role is in-person in Emeryville, CA.

  • Visa sponsorship may be available for qualified candidates.

Compensation (from employer):
$300K – $600K

About this role

Summary

Designs scalable infrastructure for large-scale AI models, prototypes, and simulations to advance neuro-AI research.

Job title

Principal Software Engineer

Experience level

senior level

Industry

software

Location requirements

In-person in emeryville, CA, no remote work allowed.

Salary

$300K – $600K

Visa sponsorship

H-1B sponsor history

Management role

No

Skills & keywords

Required skills

software engineeringsystem architecturedistributed systemsoptimizationkernel-level

Preferred skills

None specified

Specializations

distributed systemssystem architectureoptimizationneuroscienceAI
Locations

Structured locations inferred from the posting.

Emeryville, CA, USA

On-site City