Principal Scientist/Director, Translational Pharmacology

Lead the design, execution, and interpretation of preclinical pharmacology studies supporting drug discovery and development programs 
Develop and apply quantitative PK/PD models, integrating pharmacokinetics, pharmacodynamics, and chemical kinetics to guide compound optimization and dosing strategies  
Design and oversee in vivo studies, including selection and development of appropriate animal models 
Drive rigorous data analysis, including statistical evaluation and modeling to inform decision-making
Translate preclinical findings into clinically relevant hypotheses and development strategies 
Collaborate closely with teams to optimize drug candidates and delivery systems 
Contribute to regulatory documentation and strategy (IND-enabling studies, study reports, etc.)  
Build and manage relationships with CROs and external collaborators  

Qualifications

PhD, MD, or equivalent in pharmacology, biomedical sciences, or related field 
Significant experience in preclinical pharmacology within biotech or pharmaceutical settings 
Experience in choosing appropriate animal models
Deep expertise in PK/PD modeling, with strong grounding in chemical kinetics and quantitative biology 
Proven experience designing studies to evaluate drug combinations and synergy, including application of factorial experimental design Demonstrated experience designing and interpreting in vivo pharmacology studies 
Experience in advancing preclinical candidates through IND-enabling studies and contributing meaningfully to IND submissions  
Strong statistical and data analysis skills  
Experience in metabolic diseases, particularly obesity and/or diabetes, strongly preferred