In Vivo Scientist, Oncology
Pattern Biosciences
Apply to this job South San Francisco on site Until 8/21/2026 First posted March 18, 2026 Last posted March 18, 2026
Job description
We are seeking an in vivo scientist who will design and execute in vivo studies of AAV-based cancer therapeutic candidates to advance our oncology pipeline and technology platform. You will contribute to preclinical study design and lead their execution, ensuring high levels of scientific rigor and compliance with relevant regulations. This is an ideal position for a candidate with a strong background in immuno-oncology and in vivo pharmacology who thrives in a team-oriented, cross-disciplinary collaborative environment.
Primary Responsibilities
- Design and execute preclinical in vivo studies in collaboration with discovery and data scientists, develop timelines and action plans to meet company goals.
- Choose appropriate in vivo models and develop protocols with relevant endpoints for evaluating the mechanism of action, efficacy, and safety of therapeutic candidates.
- Perform hands-on in vivo experiments, including orthotopic tumor cell implantation, IV, IP and SC injections, in vivo imaging, and animal welfare monitoring.
- Perform biological sample collection and processing, MACS/FACS cell sorting, immune cell profiling using multicolor flow cytometry, immunogenicity testing using ELISA and ELISPOT, and cell-based functional assays.
- Generate, document, analyze and interpret experimental data to support critical decisions.
- Manage external laboratories and partners.
Required Skills & Qualifications
- PhD in Life Sciences with specialization in oncology or immunology.
- At least 3 years of hands-on experience working with murine tumor models in an
- industry and/or academic setting.
- Demonstrated independent ability to design, execute and interpret experimental data.
- Demonstrated experience in in vivo procedures, such as rodent surgery and IV dosing.
- Experience with tissue handling and processing, cell sorting, multi-color flow cytometry and cytokine profiling, experience with IHC and ISH is a plus
- Proficiency in mammalian cell and tissue culture.
- Detail-oriented, with strong organizational and record-keeping skills.
- Excellent communication skills and ability to collaborate effectively in a cross-functional team.
- Experience working in a GLP or regulatory-compliant environment is a plus.
At Pattern Bio, we design biological circuits at the intersection of synthetic biology and AI for cell-specific targeting of cancer tissue. By integrating data-driven design into every step—from DNA constructs to AAV-based delivery systems—we are building precise, rationally engineered, curative therapies. Our cohesive and driven team in South San Francisco is dedicated to curing cancer and saving lives.
About this role
Summary
Design and execute in vivo studies for cancer therapies, collaborate cross-functionally, support drug development,
Job title
In Vivo Scientist, Oncology
Experience level
3+ years
Industry
biotechnology
Location requirements
South San Francisco, remote work not specified
Salary
Not specified
Management role
No
Skills & keywords
Required skills
PhD in Life Sciencesmurine tumor modelsin vivo procedurescell sortingflow cytometry
Preferred skills
IHCISHregulatory environment
Specializations
immuno-oncologyin vivo pharmacologytumor modelsimmunoassayscell sorting
Locations
Structured locations inferred from the posting.
South San Francisco, CA, USA
On-site City