Senior Backend Engineer (Core Product)
Sequencing
Apply to this job US Canada remote Until 8/21/2026 5+ years exp First posted June 1, 2026 Last posted June 1, 2026
Job description
Sequencing is building the interface between humanity and its DNA.
Using clinical-grade whole genome sequencing, AI, and a rapidly expanding ecosystem of genomic applications, we help people better understand themselves, their health, and their future through their DNA.
The human genome is one of the most valuable and underutilized resources in the world. Our mission is to transform the human genome into a lifelong source of personalized guidance and build the trusted home for every genome on Earth.
As the world’s largest direct-to-consumer whole genome sequencing platform, Sequencing is helping define the future of AI-powered personalized health.
We’re a profitable, venture-backed, fully remote company building category-defining products that help people better understand themselves through their DNA.
The Position
As a Senior Backend TypeScript Engineer you build and maintain the high performance backend services that power our core personalized health experiences. You work side by side with other senior engineers to build and grow scalable infrastructure APIs and event driven services. When you do this well people get fast reliable personalized health insights from their genome instead of slow or broken experiences.
The Impact
- Design build and maintain performant backend services in TypeScript that power our core personalized experiences.
- Build and grow scalable infrastructure APIs and event driven services that deliver data driven features to users.
- Support and optimize production ready backend systems so they stay fast and dependable under load.
- Integrate and manage services such as PostgreSQL MySQL AWS SQS and Centrifugo in the backend.
- Make systems reliable secure and observable so people can trust their DNA data is safe.
- Own and drive end to end feature development with a strong eye on user experience.
- Write clean reliable code with performance and maintainability in mind from the start.
- Champion clean code technical excellence and continuous improvement across the team.
- Debug test and performance tune across services to catch problems before users feel them.
- Maintain modernize and migrate legacy code so older systems keep up with new demand.
- Take ownership of complex problems and drive them to a clear working solution.
Dominant and Expressed Traits
- 5+ years of backend development experience.
- Expert with TypeScript and comfortable owning production backend services.
- Experience with functional programming.
- Deep hands on experience with PostgreSQL MySQL and service based architectures.
- Strong debugging testing and performance tuning skills.
- Able to work independently while collaborating closely with key teammates.
- Customer driven with a passion for building systems that deliver exceptional experiences.
- Nice to have familiarity with genomics health data or personalization systems startup or fast paced environments or Rust.
About this role
Summary
Build and maintain scalable, high-performance backend services for genomic health platform.
Job title
Senior Backend Engineer (Core Product)
Experience level
5+ years
Minimum experience
5+ years exp
Industry
healthcare
Location requirements
Remote work preferred, across North and South America
Salary
Not specified
Management role
No
Skills & keywords
Required skills
typescriptpostgresqlmysqlaws sqsdebuggingperformance tuning
Preferred skills
genomicshealth datapersonalization systemsrust
Specializations
typescriptpostgresqlmysqlaws sqsservice architecture
Locations
Structured locations inferred from the posting.
United States
Remote Country
Canada
Remote Country
Unknown location
Remote
Unknown location
Remote